Design, Construction, and Validation of Perrigo API Steroids (Dry Powder) Plant

Ludan led the design management, construction, and validation of the Perrigo API (formerly Chemagis) steroid production facility, ensuring compliance with the rigorous standards of the pharmaceutical industry.

Perrigo API is one of the leading suppliers of Active Pharmaceutical Ingredients (APIs) and pharmaceutical solutions for both the generic and branded drug markets. As part of the project, a dry powder steroid API manufacturing plant was established at Ramat Hovav, Israel.

Project Scope:

✅ Conceptual and Basic Design – Development of advanced manufacturing methodologies and ensuring the plant meets international standards.
✅ Detailed Design – Including process engineering, civil engineering, mechanical and piping systems, instrumentation, control, and electrical systems.
✅ Cost Estimations and Regulatory Approvals – Managing permit requirements and ensuring compliance with strict regulatory demands.
✅ Procurement and Project Management (EPCMV) – Overseeing construction and managing the procurement of essential systems.
✅ Validation and Quality Testing (DQ & IQ Documentation, Validation) – Comprehensive documentation and compliance with international standards.

Thanks to Ludan’s professional management, the plant was constructed in full adherence to the pharmaceutical industry’s stringent standards, while optimizing production processes and ensuring optimal product quality.

Project Details:

• Client: Chemagis (Perrigo API)
• Location: Ramat Hovav, Israel
• Project Duration: 2002–2003
• Project Value: $8 million
• Field of Expertise: EPCMV (Engineering, Procurement, Construction Management, and Validation)